The loading and unloading will work. There are no dynamic forces, there's only one wheel on the gate at one time, and you yourself can step over it (I use a stepstool to get up while walking the bike up the ramp).
The problem is with the dynamic load on an uneven road. You need to get the back wheel off the gate. In the case of the 6' bed on the KC it works out so the wheels actually rest on the bed, not the gate. The gate still won't close completely as you can see in the pic, but that's ok. I've seen people with a DC load one bike at a 45 degree angle into the bed. That might work depending on the wheelbase of your bike. Just make sure you tie it down well as a brake application will induce sideways forces that way. Luckily the C channels will give you lots of freedom to tie down correctly. Best system on the market, IMHO.
At the end of the day it's probably easier to tow a trailer with a DC. I got the KC specifically to be able to drive long distances without one and thus without the speed and handling restrictions. I've done 1700km days with both bikes on at speeds of 130-150 km/h no problem, just stopping for refuel/leak/driver change. Very stable and comfortable. Total load was 420 kg for the bikes, about 120 kg for tools/ramp/winch/power pack/belts/leathers/etc., 150 kg for driver and passenger, 50 kg luggage (in the cab), and about 50 kg of tuscan wine (return trip only).

So about 800 kg. Brilliant.
Looking forward to this year's trip to the Pyrenees already...